The outcome data was obtained at 3 time points (3 months, 6 months, and 12 months) via phone or face-to-face follow-up. One-year follow-up and assessment of recurrent stroke A clinical research organization was assigned for data entry, quality control and data analysis.
#CITALOPRAM 20 MG ANTI STROKE REGISTRATION#
The data was then recorded on standard clinical study registration forms. Investigators acquired ICFs after the confirmation and registration of eligible subjects, and periodically reviewed medical records of these patients. Duration of anti-depressant drugs was determined by the clinicians according to the patients' condition.Īll investigators received standard training to proper and consistent application of DSM-IV. Categories and dose of anti-depressant drugs were as follows: Fluoxetine(10–20 mg/d), Paroxetine(10–25 mg/d), Sertraline(25–50 mg/d), Citalopram(10–20 mg/d), Venlafaxine(75–150 mg/d), Mirtazapine(15–30 mg/d). Baseline data also included intervention measures that patients received, including intravenous thrombolysis, anti-coagulation, anti-platelet, anti-hypertension, lipid lowering drug, anti-hyperglycemic drug, anti-depressant drugs and stroke patient education. Within 24 hours after admission, stroke severity was assessed according to the National Institutes of Health Stroke Scale (NIHSS), and other clinical data, including systolic and diastolic blood pressures at admission and type of stroke was recorded. This study was to investigate whether PSD at 2 weeks following a stroke increased the risk of recurrent stroke at 1 year.īaseline data of patients with acute stroke was collected at admission, including demographics (age, gender), and vascular disease risk factors such as hypertension (history of hypertension or anti-hypertension drug), diabetes (history of diabetes or anti-hypoglycemic drug), hyperlipidemia (history of hyperlipidemia or lipid lowering drug), history of stroke, history of cardiac disease, smoking (smoking at present or within 1 month), and high alcohol consumption (≥5 standard drink/day). Moreover, although anti-depressant drugs had been historically applied in clinical, there were few studies on the effect of anti-depressant drugs on the recurrent stroke and the conclusions of these reports were not consistent –. Some other studies failed to show such correlation –. Some studies have shown that depression increases the risk of first stroke and recurrent stroke by 45% to 80% –.
In addition, the conclusions from previous studies on the correlation between depression and recurrent strokes are inconsistent. However, whether PSD increases the risk of recurrent stroke requires further investigation. Studies have showed that PSD increases the mortality rate at 1 year following a stroke. PSD is the most common psychological disorder among stroke survivors. Ellekjaer H et al reported a doubled mortality rate in patients with recurrent strokes compared to that of the initial stroke. Previous studies showed an even higher rate of recurrent stroke, reaching 16%, among Chinese stroke patients. A meta-analysis reported that nearly 11.1% of the patients suffered recurrent stroke at 1 year. With the advances in diagnostic and therapeutic techniques, the treatment and prevention of stroke have greatly improved, however, recurrent stroke remains a problem requiring immediate attention. In China, stroke has surpassed coronary artery disease to be the number one cause of morbidity and mortality of adults. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. 2006BA101A11, This study was also supported by Pfizer Pharmaceutical Company ( This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. 2009-009, and the National 11th Five-year Scientific and Technological Brainstorm Project (grant No. 81071115, the Young Scientists Fund of the Beijing Health Bureau (grant No. 7102050, the National Science Foundation (grant no. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This study was funded jointly by the Beijing Science and Technology Committee (grant no. Received: Accepted: SeptemPublished: October 17, 2012Ĭopyright: © Yuan et al. (2012) Poststroke Depression and Risk of Recurrent Stroke at 1 Year in a Chinese Cohort Study. Citation: Yuan HW, Wang CX, Zhang N, Bai Y, Shi YZ, Zhou Y, et al.
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